KW-2478 (b)

Research use only, not for human use.

KW-2478 (KW2478) is a novel potent Hsp90 inhibitor with IC50 of 3.8 nM (Hsp90α), exhibits antitumor activities both in vitro and in vivo.

KW-2478 (KW2478) is a novel potent Hsp90 inhibitor with IC50 of 3.8 nM (Hsp90α), exhibits antitumor activities both in vitro and in vivo; demonstrates antiproliferative activities against human MM cells, OPM-2/GFP, KMS-11, RPMI 8226, and NCI-H929 with IC50 of 0.30, 0.34, 0.39, and 0.12 uM respectively, associated with degradation of well-known client proteins as well as FGFR3, c-Maf, and cyclin D1; suppresses tumor growth in NCI-H929 models.Blood Cancer Phase 2 Discontinued.

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KW2478 | KW 2478

Cytoskeleton/Cell Adhesion Molecules

HSP

HSP

Cancer

Blood cancer

819812-18-5

611.129

C30H43ClN2O9

>98% (HPLC)

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CCC1=C(C(=C(C=C1O)O)C(=O)C2=CC(=C(C=C2)OCCN3CCOCC3)OC)CC(=O)N(CCOC)CCOC.Cl

2-{2-ethyl-3,5dihydroxy-6-[3-methoxy-4-(2-morpholin-4-ylethoxy)benzoyl]phenyl}-N,N-bis(2-methoxyethyl)acetamide monohydrochloride

(-20℃)

With Ice Pack

≥ 2 years